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            Veterinary Updates &amp; Insights   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏   ͏
        
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      <div class="section-caption-text" style="position:relative;"><h4 style="margin:1.414em 0 .5em;font-weight:400;font-size:1.2496875em;mso-line-height-alt:1.2496875em;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;letter-spacing:.02em;color:#000;line-height:normal;margin-top:0px;margin-bottom:16px;"><strong>Gabapentin's Effect on Blood Pressure in Cats</strong></h4><p class="" style="font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;">Gabapentin is often used to reduce stress in cats, but its effects on BP remain unclear. This randomized, blinded, placebo-controlled crossover study evaluated gabapentin’s impact on BP in 16 healthy cats and 13 cats with stable CKD. Three hours after receiving 10 mg/kg of gabapentin or a placebo (administered randomly one week apart), BP was measured. Gabapentin lowered BP by a median of 12 mm Hg in both groups, though individual responses varied significantly.</p><p class="" style="font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;">The study found that cats with higher serum gabapentin concentrations experienced greater BP reductions. While gabapentin may help facilitate BP measurement in anxious or uncooperative cats, the most reliable readings come from calm, non sedated patients.</p><p class="" style="font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;margin-bottom:0;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;">Read the full article<a href="https://journals.sagepub.com/doi/full/10.1177/1098612X241240326" rel="nofollow" style="color:#000 !important;"> here</a></p></div>
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    <table role="presentation" width="100%" cellpadding="0" cellspacing="0" border="0" align="center" class="side-layout" style="width:100% !important;"><tbody><tr><td class="section-text-cell" style="padding-top:22px;padding-right:22px;padding-bottom:22px;padding-left:22px;">
      <div class="section-caption-text" style="position:relative;"><h4 style="margin:1.414em 0 .5em;font-weight:400;font-size:1.2496875em;mso-line-height-alt:1.2496875em;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;letter-spacing:.02em;color:#000;line-height:normal;margin-top:0px;margin-bottom:16px;"><strong>Gonadectomy and CCL Disease Risk in Dogs</strong></h4><p style="font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;margin-top:1rem;" class="">A recent meta-analysis by Dr. Daniel Low reviewed 24 studies, analyzing data from over 1.8 million dogs to explore the link between gonadectomy and cranial cruciate ligament (CCL) disease.</p><p style="font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;margin-top:1rem;" class=""><strong>Key Findings:</strong></p><ul data-rte-list="default" style="padding-left:25px;"><li style="font-weight:normal;margin-top:0px;margin-bottom:0px;margin-left:15px;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;"><p class="" style="font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;margin-top:0;margin-bottom:0;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;">Gonadectomy is associated with a <strong>twofold increase in CCL disease risk</strong> in both male and female dogs.</p></li><li style="font-weight:normal;margin-top:0px;margin-bottom:0px;margin-left:15px;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;"><p class="" style="font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;margin-top:0;margin-bottom:0;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;">However, when performed <strong>after 1 year of age</strong>, the risk appears to decrease—though not significantly.</p></li></ul><p class="" style="font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;"><strong>Limitations:</strong></p><ul data-rte-list="default" style="padding-left:25px;"><li style="font-weight:normal;margin-top:0px;margin-bottom:0px;margin-left:15px;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;"><p class="" style="font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;margin-top:0;margin-bottom:0;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;">All included studies were <strong>observational</strong>, so a direct causal link cannot be confirmed.</p></li><li style="font-weight:normal;margin-top:0px;margin-bottom:0px;margin-left:15px;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;"><p class="" style="font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;margin-top:0;margin-bottom:0;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;">The risk of CCL disease is <strong>breed-dependent</strong>, meaning results may not apply to all dogs.</p></li></ul><p class="" style="font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;"><strong>Study Recommendations:</strong></p><ul data-rte-list="default" style="padding-left:25px;"><li style="font-weight:normal;margin-top:0px;margin-bottom:0px;margin-left:15px;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;"><p class="" style="font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;margin-top:0;margin-bottom:0;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;"><strong>Delaying gonadectomy</strong> until musculoskeletal maturity (≈12 months for small breeds, up to 24 months for giant breeds) may help reduce orthopedic risks.</p></li><li style="font-weight:normal;margin-top:0px;margin-bottom:0px;margin-left:15px;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;"><p class="" style="font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;margin-top:0;margin-bottom:0;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;">Decisions should be <strong>individualized</strong>, taking into account breed, cancer risk, urinary health, and behavior.</p></li></ul><p class="" style="font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;margin-bottom:0;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#000;">Read full article<a href="https://onlinelibrary.wiley.com/doi/10.1111/vsu.14197" rel="nofollow" style="color:#000 !important;"> here </a></p></div>
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      <p class="" style="color:inherit;font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;margin-top:0;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;"><strong>Librela Update: New Labeling Reflects Reported Adverse Events</strong></p><p class="" style="color:inherit;font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;">Librela, the monoclonal antibody for managing osteoarthritis pain in dogs, has faced scrutiny following numerous client complaints and class-action lawsuits. In response, Zoetis has updated Librela’s U.S. label to include post-approval adverse event data.</p><p class="" style="color:inherit;font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;">The newly listed side effects, reported in decreasing frequency, include neurological issues (ataxia, seizures, paralysis), general symptoms (lethargy, anorexia), urinary concerns, gastrointestinal upset, and musculoskeletal effects. In some cases, adverse reactions have led to euthanasia.</p><p class="" style="color:inherit;font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;margin-bottom:0;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;">Read more<a href="https://www.zoetisus.com/products/dogs/librela-a-new-era-in-treatment" rel="nofollow" style="color:#000 !important;"> here </a>and <a href="https://www.businesswire.com/news/home/20250203254176/en/Zoetis-Announces-U.S.-Label-Update-for-Librela®-bedinvetmab-injection-a-Treatment-to-Control-Canine-Osteoarthritis-OA-Pain/?_bhlid=aec74d4185ccfa26ce6a6c5759febbde927f1234&amp;utm_campaign=who-regulates-pet-food&amp;utm_medium=newsletter&amp;utm_source=weekend-rounds.beehiiv.com" rel="nofollow" style="color:#000 !important;">here </a></p>
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      <div class="section-caption-text" style="position:relative;"><p class="" style="font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;margin-top:0;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#313131;"><strong>A donkey and a yoga ball - who would have thought it’d be the perfect duo? </strong>Diesel, a lonely donkey, was heartbroken when his beloved yoga ball deflated. His owner shared his story online, and the internet responded with kindness - people donated dozens of new yoga balls to keep Diesel entertained. Now, he’s back to playing happily, proving that even small gestures can bring big joy.</p><p class="" style="font-size:.9375em;line-height:1.618em;margin:0 0 1.25em 0;font-weight:normal;margin-bottom:0;font-family:Palatino, Palladio, Baskerville, 'Nimbus Roman No9 L', Garamond, 'Century Schoolbook', serif;color:#313131;">Read the full story<a href="https://www.goodnewsnetwork.org/after-his-beloved-yoga-ball-deflates-lonely-donkey-receives-donated-balls-from-across-bc/" rel="nofollow" style="color:#000 !important;"> here </a></p></div>
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